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February 2014

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“Randomized controlled clinical trials are the gold standard for developing medication.” Fargo told CBS News. “But to be frank, you really can’t do that kind of study on some of the modifiable risk factors. In some ways that would be unethical to do.”

For example, it would be unethical for scientists to take people who are 65 years old living with high blood pressure and treat some of them and not others to see what happens for their risk of dementia.

“There’s some understanding in the scientific community that we don’t want to leave certain interventions on the table just because they’re not amenable randomized controlled clinical trials,” Fargo said.

When taken in that context, he said the new reviews aren’t nearly as pessimistic as they appear at first look.

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